England spinner Jack Leach has been ruled out from the remaining three Tests against India due to a left knee injury, as announced by the country's cricket board on Sunday.
The series stands at 1-1 after two matches and is set to recommence in Rajkot for the third Test starting on Thursday.
"Leach sustained the injury during England's first Test victory in Hyderabad and missed the second Test," the England and Wales Cricket Board (ECB) said in a statement.
"England will not be calling up a replacement," it added.
England, led by Ben Stokes, won the opener to hand the hosts just their fourth loss at home since 2013 but Rohit Sharma's team bounced back in the next match with a 106-run victory.
England is currently in Abu Dhabi, where the 32-year-old Somerset spinner will fly home from, said the ECB.
Earlier, it was confirmed that Virat Kohli will miss the remaining three tests of their five-match home series with England for personal reasons.
Kohli withdrew from the first two Tests, also for personal reasons. The BCCI said in a statement that it fully respected and supported the former captain’s decision.
The 35-year-old former captain, who has notched up nearly 9,000 runs in 113 Tests, will miss an entire home series for the first time in his career.
England won the first Test by 28 runs in Hyderabad before the hosts levelled the series at 1-1 with a 106-run win at Visakhapatnam this week.
The third Test is scheduled to take place in Rajkot from Thursday, with matches to follow at Ranchi and Dharamsala.